Research Article

Human leucocyte antigens A, B, C, and DRW in idiopathic "warm" autoimmune haemolytic anaemia.

Br Med J 1980; 280 doi: https://doi.org/10.1136/bmj.280.6216.760 (Published 15 March 1980) Cite this as: Br Med J 1980;280:760
  1. A Abdel-Khalik,
  2. L Paton,
  3. A G White,
  4. S J Urbaniak

    Abstract

    Twenty patients with idiopathic "warm" autoimmune haemolytic anaemia and 40 controls were types concurrently for human leucocyte antigens (HLA) A, B, C, and DRW. There was a significantly stronger association of HLA-B8 with the disease (chi 2 = 10.39; p = 0.018) than HLA-DRW3 (chi 2 = 3.71; P = 0.35) and the patients also showed a significant increase in BW6 homozygosity (chi 2 = 7.13; P = 0.01) and a corresponding reduction in BW4 (chi 2 = 7.13; P = 0.02). (All p values corrected for number of antigens at each locus.) These findings suggest that susceptibility to idiopathic autoimmune haemolytic anaemia is associated more closely with the HLA-B locus than with DRW3.