Research Article

Evidence that type I diabetes and thyrogastric autoimmunity have different genetic determinants.

Br Med J 1980; 280 doi: https://doi.org/10.1136/bmj.280.6208.145 (Published 19 January 1980) Cite this as: Br Med J 1980;280:145
  1. A N Gorsuch,
  2. B M Dean,
  3. G F Bottazzo,
  4. J Lister,
  5. A G Cudworth

    Abstract

    The prevalences of autoimmune endocrine disease and relevant organ-specific autoantibodies were determined in 141 patients with type I (insulin-dependent) diabetes and their families. All available members of the families were genotyped for HLA. Islet-cell antibody was found in 10 (4%) out of 248 unaffected siblings, all of whom were genetically potential cases of diabetes. One developed classical symptoms six months later. In contrast, thyroid and gastric parietal-cell antibodies occurred independent of the HLA-linked susceptibility to diabetes. These results suggest that different genes control the production of these autoantibodies and the susceptibility to type I diabetes.