Resetting of osmoreceptor response as cause of hyponatraemia in acute idiopathic polyneuritis.Br Med J 1979; 2 doi: https://doi.org/10.1136/bmj.2.6203.1474 (Published 08 December 1979) Cite this as: Br Med J 1979;2:1474
- M D Penney,
- D Murphy,
- G Walters
In a patient with hyponatraemia associated with acute idiopathic polyneuritis plasma concentrations of antidiuretic hormone increased when hypertonic saline was infused intravenously, and urine osmolality rose concomitantly. A water load was excreted normally, while the plasma remained extremely hypo-osmolal. It is concluded that osmoregulation was functioning normally but was set abnormally low, possibly owing to a disturbance of the peripheral volume receptors.