Immunological effect of co-trimoxazole on platelets.Br Med J 1979; 2 doi: http://dx.doi.org/10.1136/bmj.2.6195.898 (Published 13 October 1979) Cite this as: Br Med J 1979;2:898
- F H Claas,
- J W van der Meer,
- J Langerak
Diminished survival of transfused platelets occurred in two patients given co-trimoxazole, and a third patient taking this drug developed thrombocytopenia. By means of an indirect immunofluorescence assay antibodies against donor platelets coated with co-trimoxazole were found in the sera in all cases. These antibodies were directed against the trimethoprim component of co-trimoxazole and not against sulphamethoxazole. Co-trimoxazole is a potent antimicrobial agent and is advocated for treatment and prophylaxis in leukaemia. Hence its adverse effect on platelets is of great importance.