Research Article

Immunological effect of co-trimoxazole on platelets.

BMJ 1979; 2 doi: http://dx.doi.org/10.1136/bmj.2.6195.898 (Published 13 October 1979) Cite this as: BMJ 1979;2:898

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  1. F H Claas,
  2. J W van der Meer,
  3. J Langerak

    Abstract

    Diminished survival of transfused platelets occurred in two patients given co-trimoxazole, and a third patient taking this drug developed thrombocytopenia. By means of an indirect immunofluorescence assay antibodies against donor platelets coated with co-trimoxazole were found in the sera in all cases. These antibodies were directed against the trimethoprim component of co-trimoxazole and not against sulphamethoxazole. Co-trimoxazole is a potent antimicrobial agent and is advocated for treatment and prophylaxis in leukaemia. Hence its adverse effect on platelets is of great importance.