Research Article

Effects of inflammatory disease on plasma oxprenolol concentrations.

Br Med J 1979; 2 doi: https://doi.org/10.1136/bmj.2.6188.465 (Published 25 August 1979) Cite this as: Br Med J 1979;2:465
  1. M J Kendall,
  2. C P Quarterman,
  3. H Bishop,
  4. R E Schneider

    Abstract

    When single oral doses of oxprenolol were given to three healthy subjects on three separate occasions under standardised conditions the plasma concentration-time curves for each subject were closely similar. In two of the subjects, however, a mild illness led to a dramatic, temporary increase in the peak plasma concentration and area under the plasma concentration-time curve (AUC). This effect of inflammatory disease was confirmed by comparing a group of patients with an erythrocyte sedimentation rate (ESR) of over 20 mm in the first hour with a group whose ESR was below this value. The mean peak plasma concentration and AUC were significantly higher in the group with a raised ESR. This may be related to altered concentrations of one of the acute-phase proteins. Thus it is concluded that plasma oxprenolol concentrations are raised in inflammatory disease, but further work is needed to determine the mechanism of this increase.