Increased exercise tolerance with nitrates in beta-blockaded patients with angina.Br Med J 1977; 2 doi: https://doi.org/10.1136/bmj.2.6086.550 (Published 27 August 1977) Cite this as: Br Med J 1977;2:550
- R H Baxter,
- I M Lennox
In 14 beta-blockaded anginal subjects, 10 of whom had poor left ventricular function, sublingual isosorbide dinitrate significantly increased maximal exercise capacity on a standardized multistage treadmill test. This was associated with changes in heart rate and blood pressure suggestive of a fall in left ventricular work. The effect of isosorbide lasts for at least two hours and when taken before exercise may be a useful addition to beta-blockade in patients with angina.