Research Article

Coagulation and fibrinolysis in intact hydatidiform molar pregnancy.

Br Med J 1976; 2 doi: https://doi.org/10.1136/bmj.2.6050.1481 (Published 18 December 1976) Cite this as: Br Med J 1976;2:1481
  1. F H Tsakok,
  2. S Koh,
  3. S S Ratnam

    Abstract

    Tests of coagulation, fibrinolysis, and platelet function were performed in 17 patients with intact molar pregnancies. Women with intact molar pregnancies had higher fibrinogen factor VIII, and fibrinogen degradation products, concentrations and lower prothrombin, factor X, plasminogen, and plasminogen activator concentrations than controls with normal pregnancies. They also had reduced platelet counts and thromboelastographic values, which indicated hypocoagulability. These results suggest that intravascular coagulation occurs in intact hydatidiform molar pregnancies.