Research Article

Endotoxaemia and renal failure in cirrhosis and obstructive jaundice.

Br Med J 1976; 2 doi: https://doi.org/10.1136/bmj.2.6049.1415 (Published 11 December 1976) Cite this as: Br Med J 1976;2:1415
  1. S P Wilkinson,
  2. H Moodie,
  3. J D Stamatakis,
  4. V V Kakkar,
  5. R Williams

    Abstract

    An investigation into the possible role of endotoxins in the pathogenesis of renal failure in cirrhosis and obstructive jaundice showed the two to be closely related. None of the patients with cirrhosis who had endotoxaemia had other evidence of Gram-negative infection at the time of the study, and the endotoxaemia was therefore probably due to impaired hepatic clearance of toxins normally absorbed from the gastrointestinal tract. In contrast, bacteriological evidence of Gram-negative infection was found in most of the patients with obstructive jaundice and endotoxaemia.