Research Article

Weak autoantibody reactions to antigens other than sperm after vasectomy.

Br Med J 1976; 2 doi: (Published 04 December 1976) Cite this as: Br Med J 1976;2:1359
  1. J D Mathews,
  2. D C Skegg,
  3. M P Vessey,
  4. M Konice,
  5. E J Holborow,
  6. J Guillebaud


    Autoantibody activity against various antigens was measured by indirect immunofluorescence in 97 men about to undergo vasectomy and 170 men who had undergone the operation up to six years earlier. There was a significantly higher prevalence of weakly positive autoantibody reactions among those who had undergone vasectomy. There was, however, no evidence that vasectomy could induce stronger autoantibody reactions such as those associated with autoimmune disease.