Research Article

Tobramycin, amikacin, sissomicin, and gentamicin resistant Gram-negative rods.

Br Med J 1976; 2 doi: https://doi.org/10.1136/bmj.2.6047.1284 (Published 27 November 1976) Cite this as: Br Med J 1976;2:1284
  1. F A Drasar,
  2. W Farrell,
  3. J Maskell,
  4. J D Williams

    Abstract

    Sensitivities to gentamicin, sissomicin, tobramycin, and amikacin were compared in 196 gentamicin-resistant Gram-negative rods and in 212 similar organisms sensitive to gentamicin, mainly isolated from clinical specimens. Amikacin was the aminoglycoside most active against gentamicin-resistant organisms, Pseudomonas aeruginosa, klebsiella spp, Escherichia coli, Proteus spp, Providencia spp, and Citrobacter spp being particularly susceptible. Most of the gentamicin-resistant organisms were isolated from the urine of patients undergoing surgery. Gentamicin was the most active antibiotic against gentamicin-sensitive E coli, Proteus mirabilis, and Serratia spp. Pseudomonas aeruginosa and other Pseudomonas spp were most susceptible to tobramycin.