Research Article

Muscle changes in acromegaly.

Br Med J 1976; 2 doi: (Published 16 October 1976) Cite this as: Br Med J 1976;2:914
  1. M Nagulesparen,
  2. R Trickey,
  3. M J Davies,
  4. J S Jenkins


    Muscle biopsy specimens were obtained from 18 patients with acromegaly of varying degrees of severity. Half the specimens showed hypertrophy of type 1 fibres, while atrophy was most often seen in type 2 fibres. A direct correlation between muscle appearances and growth hormone levels was not observed. The needle biopsy technique is particularly suitable for determining the natural history of acrometalic myopathy.