Muscle changes in acromegaly.Br Med J 1976; 2 doi: https://doi.org/10.1136/bmj.2.6041.914 (Published 16 October 1976) Cite this as: Br Med J 1976;2:914
- M Nagulesparen,
- R Trickey,
- M J Davies,
- J S Jenkins
Muscle biopsy specimens were obtained from 18 patients with acromegaly of varying degrees of severity. Half the specimens showed hypertrophy of type 1 fibres, while atrophy was most often seen in type 2 fibres. A direct correlation between muscle appearances and growth hormone levels was not observed. The needle biopsy technique is particularly suitable for determining the natural history of acrometalic myopathy.