Research Article

Long-term low-dose co-trimoxazole in prophylaxis of childhood urinary tract infection: clinical aspects.

Br Med J 1976; 2 doi: https://doi.org/10.1136/bmj.2.6029.203 (Published 24 July 1976) Cite this as: Br Med J 1976;2:203
  1. J M Smellie,
  2. R N Grüneberg,
  3. A Leakey,
  4. W S Atkin

    Abstract

    Long-term low-dosage prophylaxis may be used in children with recurrent urinary tract infection to prevent reinfection of the urinary tract while the underlying cause of infection persists. Co-trimoxazole in a dose of 2 mg trimethoprin combined with 10 mg sulphamethoxazole per kg body weight daily has proved very effective: only six of 130 children receiving this treatment during a total period of 2637 months developed a reinfection. Co-trimoxazole was acceptable, compliance was good, and there were no important adverse effects. Supportive measures during prophylaxis are important. Sixty-five children were follow up after completion of their co-trimoxazole prophylaxis. Twenty-seven developed reinfections with fresh organisms, over two-thirds occurring within three months of discontinuing prophylaxis. Each one of these reinfections was sensitive to trimethoprin. The rectal flora were similarly sensitive.