Research Article

Propranolol in hypertension: a dose-response study.

Br Med J 1976; 2 doi: https://doi.org/10.1136/bmj.2.6028.140 (Published 17 July 1976) Cite this as: Br Med J 1976;2:140

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  1. D B Galloway,
  2. S C Glover,
  3. W G Hendry,
  4. A W Logie,
  5. J C Petrie,
  6. M C Smith,
  7. J A Lewis,
  8. W T Simpson

    Abstract

    The effect of propranolol was studied in a double-blind crossover trial in 24 carefully selected hypertensive outpatients. Each patient received propranolol 60 mg/day, 120 mg/day, 240 mg/day, and placebo for four weeks each according to a randomised sequence. Propranolol 60 mg/day was no better than placebo in reducing blood pressure. The effects of propranolol 120 mg/day and 240 mg/day were not significantly different. Both doses reduced lying blood pressure by about 20/10 mm Hg from an initial level of 173/104 mm Hg. No difference was detected between the effects of the different doses of propranolol and placebo on weight or on the occurrence of adverse reactions.