Immune status of children with and without severe infection during remission of malignant disease.Br Med J 1975; 2 doi: https://doi.org/10.1136/bmj.2.5969.467 (Published 31 May 1975) Cite this as: Br Med J 1975;2:467
- J Graham-Pole,
- M L Willoughby,
- S Aitken,
- A Ferguson
The immune status of children with malignant disease in remission was assessed usingvarious immune function tests. Children with infections had significantlymore neutropenia, hypogammaglobulinaemia, and impaired cell-mediated immune responses than those without. These two groups combined had much more absolute lymphopenia and impairment of both cell-mediated immunity and antibody-producing capacity thancontrol children with non-malignant conditions. Regular immunological evaluation isrecommended for children with malignant disease when new intensive treatment schedules are under trial and for individual patients particularly prone to develop infections during treatment.