Research Article

Relief of duodenal ulcer sysmptons by oral metiamide.

Br Med J 1975; 2 doi: (Published 10 May 1975) Cite this as: Br Med J 1975;2:307
  1. R E Pounder,
  2. J G Williams,
  3. G J Milton-Thompson,
  4. J J Misiewicz


    Thirty patients with symptoms of duodenal ulceration were treated for five to eight weeks in a double-blind trial with either metiamide 1 g daily by mouth or a placebo. In the 15 patients receiving metiamide there were significant reductions in nocturnal pain and antacid consumption. Daytime pain was diminished. The results suggest that histamine H2-receptor antagonists are likely to be useful in the medical management of the symptoms of duodenal ulceration.