Research Article

Hypersecretion of glucagon and gastrin in severely burnt patients.

Br Med J 1975; 2 doi: (Published 26 April 1975) Cite this as: Br Med J 1975;2:170
  1. C I Orton,
  2. A W Segal,
  3. S R Bloom,
  4. J Clarke


    Hyperglucagonaemia and hypergastrinaemia were observed in some severely burnt patients during their illness. Hyperglucagonaemia seemed to be related to the severity of illness rather than to the burn itself, and the close correlation of glucagon concentrations with glucose and urea and its inverse correlation with bicarbonate concentrations suggest that glucagon might contribute to the hypercatabolic state. One patient developed high levels of gastrin and massive bleeding from a stress ulcer of the duodenum. Possibly gastrin hypersecretion may have a role in the pathogenesis of Curling's ulcer.