Papers And Originals

Measurement of Side Effects of Drugs

Br Med J 1974; 2 doi: (Published 29 June 1974) Cite this as: Br Med J 1974;2:698
  1. E. C. Huskisson,
  2. J. A. Wojtulewski


    In a clinical trial of two antirheumatic agents two methods of collection of side effects were used, one with and the other without a check list of possible symptoms. Findings suggested that the use of a check list interfered with the collection of side effects. Known side effects of aspirin—tinnitus, deafness, and gastrointestinal disturbance—were more efficiently shown and symptoms not included in the check list were more likely to be reported when a check list was not used.