Degree and Duration of Reversal by Naloxone of Effects of Morphine in Conscious SubjectsBr Med J 1974; 2 doi: https://doi.org/10.1136/bmj.2.5919.589 (Published 15 June 1974) Cite this as: Br Med J 1974;2:589
- J. M. Evans,
- M. I. J. Hogg,
- J. N. Lunn,
- M. Rosen
The effects of intravenous naloxone on several of the actions of intravenous morphine (mean dose 30 mg/70 kg) were studied in six volunteer subjects. Naloxone produced a well defined reversal of the respiratory depression, analgesia, and miotic and subjective effects of the morphine. The agonist action of morphine outlasted the antagonist action of a single dose of naloxone. The effect of repeated doses of naloxone was also short-lived, but continuous infusions were effective in maintaining reversal.