Papers And Originals

Degree and Duration of Reversal by Naloxone of Effects of Morphine in Conscious Subjects

Br Med J 1974; 2 doi: https://doi.org/10.1136/bmj.2.5919.589 (Published 15 June 1974) Cite this as: Br Med J 1974;2:589

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  1. J. M. Evans,
  2. M. I. J. Hogg,
  3. J. N. Lunn,
  4. M. Rosen

    Abstract

    The effects of intravenous naloxone on several of the actions of intravenous morphine (mean dose 30 mg/70 kg) were studied in six volunteer subjects. Naloxone produced a well defined reversal of the respiratory depression, analgesia, and miotic and subjective effects of the morphine. The agonist action of morphine outlasted the antagonist action of a single dose of naloxone. The effect of repeated doses of naloxone was also short-lived, but continuous infusions were effective in maintaining reversal.