Papers And Originals

Urinary Excretion of Fibrinogen-related Materials, Complement, and Immunoglobulins in Proliferative Glomerulonephritis and after Renal Transplantation

Br Med J 1974; 2 doi: (Published 08 June 1974) Cite this as: Br Med J 1974;2:535
  1. M. S. Hoq,
  2. J. L. Anderton,
  3. M. Cunningham,
  4. John D. Cash


    Using a radial immunodiffusion technique we measured the urinary concentration of material related to complement (C3), IgM, and IgG along with fibrin-fibrinogen degradation products and heterophile (sheep) haemagglutinins in 15 patients with proliferative glomerulonephritis and in 10 patients after renal transplantation. There was a significant correlation between all variables measured, and serial studies showed that with the exception of IgG-related materials potentially useful information could be obtained on the detection of rejection and the response to treatment in both conditions. The significance of these observations is discussed.