Papers And Originals

Idoxuridine in Herpes Zoster: Further Evaluation of Intermittent Topical Therapy

Br Med J 1974; 2 doi: https://doi.org/10.1136/bmj.2.5918.526 (Published 08 June 1974) Cite this as: Br Med J 1974;2:526
  1. Rodney Dawber

    Abstract

    In a randomized double-blind controlled trial of the value of intermittent topical idoxuridine in treating herpes zoster in 118 patients idoxuridine 5% in 100% dimethyl sulphoxide (DMSO), applied four-hourly for four days, significantly shortened the vesicular phase, healing time, and duration of pain; idoxuridine 25% applied two-hourly produced no greater benefit. The only side effects were transient tender erythema in three patients and “urticarial” oedema in two patients with dermographia.