Papers And Originals

Gastric Response to Metiamide

Br Med J 1974; 2 doi: https://doi.org/10.1136/bmj.2.5914.304 (Published 11 May 1974) Cite this as: Br Med J 1974;2:304
  1. B. Thjodleifsson,
  2. K. G. Wormsley

    Abstract

    Metiamide greatly reduced pentagastrin-stimulated and overnight secretion of acid and pepsin in 11 patients with duodenal ulcer and virtually abolished gastric secretion in three patients with gastric ulcer. The drug was equally effective when infused intravenously or intraduodenally. A therapeutic trial of Metiamide is warranted in diseases caused or aggravated by excess gastric secretion of acid and pepsin.