Papers And Originals

Response to Rimiterol and Salbutamol Aerosols Administered by Intermittent Positive-pressure Ventilation

Br Med J 1974; 2 doi: https://doi.org/10.1136/bmj.2.5913.250 (Published 04 May 1974) Cite this as: Br Med J 1974;2:250
  1. N. J. Cooke,
  2. J. A. Kerr,
  3. R. F. Willey,
  4. Margaret V. Hoare,
  5. I. W. B. Grant,
  6. G. K. Crompton

    Abstract

    The bronchodilator and cardiac effects produced by aerosols of 0·5% salbutamol and 0·5% and 1% rimiterol administered for three minutes in 40% oxygen by intermittent positive-pressure ventilation (I.P.P.V.) were compared in 15 asthmatic patients. Salbutamol and both the concentrations of rimiterol were equipotent in peak bronchodilator effect, but salbutamol had a significantly longer duration of bronchodilator action. There was significantly less increase in heart rate after rimiterol than after salbutamol. Aerosols of 0·5% rimiterol, 0·5% salbutamol, and saline were administered by I.P.P.V. to 10 normal volunteers. There was no difference between the mean heart rates after 0·5% rimiterol and saline but a highly significant increase in mean heart rate was observed after 0·5% salbutamol. It was concluded that 0·5% rimiterol was an effective short-acting bronchodilator drug with little or no cardiac beta1-adrenergic activity when administered for three minutes by I.P.P.V. in 40% oxygen.