Choreo-athetosis and Encephalopathy Induced by PhenytoinBr Med J 1974; 2 doi: https://doi.org/10.1136/bmj.2.5912.204 (Published 27 April 1974) Cite this as: Br Med J 1974;2:204
- D. L. McLellan,
- M. Swash
Two patients with intractable epilepsy who had been treated with various combinations of anticonvulsant drugs developed phenytoin encephalopathy. In both patients choreo-athetoid involuntary movements were prominent. Blood phenytoin concentrations were above 30 μg/ml. When phenytoin was given in smaller doses and its level in the blood fell the involuntary movements and other clinical manifestations disappeared.