Papers And Originals

Choreo-athetosis and Encephalopathy Induced by Phenytoin

Br Med J 1974; 2 doi: https://doi.org/10.1136/bmj.2.5912.204 (Published 27 April 1974) Cite this as: Br Med J 1974;2:204
  1. D. L. McLellan,
  2. M. Swash

    Abstract

    Two patients with intractable epilepsy who had been treated with various combinations of anticonvulsant drugs developed phenytoin encephalopathy. In both patients choreo-athetoid involuntary movements were prominent. Blood phenytoin concentrations were above 30 μg/ml. When phenytoin was given in smaller doses and its level in the blood fell the involuntary movements and other clinical manifestations disappeared.