Papers And Originals

Immunoglobulin Deposition in Liver of Patients with Active Chronic Hepatitis and Antibody against Smooth Muscle

BMJ 1973; 2 doi: (Published 16 June 1973) Cite this as: BMJ 1973;2:643
  1. R. L. Dawkins,
  2. R. A. Joske


    Liver biopsies from 33 patients with miscellaneous liver diseases were studied by direct immunofluorescence. Three patients with active chronic hepatitis possessed a distinctive pattern of staining with anti-IgG conjugate. They were relatively young women and all three possessed the anti-smooth-muscle antibody. In addition, all three were untreated at the time of study. It is suggested that direct immunofluorescence on liver biopsies may help in the investigation of liver disease and that humoral immunity may participate in the pathogenesis of active chronic hepatitis.