Papers And Originals

Hereditary Giant Platelet Syndrome: A Disorder of a New Aspect of Platelet Function

Br Med J 1973; 2 doi: https://doi.org/10.1136/bmj.2.5866.586 (Published 09 June 1973) Cite this as: Br Med J 1973;2:586
  1. Margaret A. Howard,
  2. R. A. Hutton,
  3. R. M. Hardisty

    Abstract

    The platelets of three patients with the hereditary giant platelet syndrome of Bernard and Soulier failed to aggregate in response to either ristocetin or bovine fibrinogen. The results of aggregation experiments using mixtures of platelets and plasma suggest that a reaction between a plasma factor deficient in von Willebrand's disease and a platelet component lacking in our patients, and leading to platelet aggregation independently of adenosine diphosphate (ADP), is essential for normal haemostasis.