Papers And Originals

Prospective Study of Cytomegalovirus Infection in Pregnancy

Br Med J 1973; 2 doi: https://doi.org/10.1136/bmj.2.5861.268 (Published 05 May 1973) Cite this as: Br Med J 1973;2:268
  1. H. Stern,
  2. S. M. Tucker

    Abstract

    In a prospective study of cytomegalovirus infection in 1,040 pregnant women in London 319 (42%) of the white Englishwomen but only 28 (10%) of the immigrant Asian women were without antibodies at the onset of pregnancy. Out of 254 susceptible white women and 16 susceptible Asian women 8 (3%) and 3 (16%) respectively experienced primary infection during the course of pregnancy. The overall incidence of fetal infection after primary infection in the mother was almost 50%, and was higher in early pregnancy. One out of the five infected infants was found to be mentally retarded.

    Reactivation of latent infection was recognized in 0·7-2·9% of pregnant women; this occurred without involving the fetus.