Papers And Originals

Immunological Abnormalities and Hydantoins

Br Med J 1972; 2 doi: http://dx.doi.org/10.1136/bmj.2.5813.561 (Published 03 June 1972) Cite this as: Br Med J 1972;2:561
  1. Peter J. Grob,
  2. Gian E. Herold

    Abstract

    Various immunological features were measured in 20 patients with epilepsy who had received prolonged treatment with hydantoins. Immunoglobulin A (IgA) was shown to be absent or low in five patients, β1C/A was low in 10 patients. Five patients showed negative reactions to skin tests, and two could not be sensitized to dinitrochlorobenzene. The corresponding features were normal in 14 control patients with epilepsy but without hydantoins. It is suggested that the hydantoins influence humoral immunity, whereas other immunosuppressant agents have been found to affect cellular immunity.