Papers And Originals

Protection of Rat Bronchial Epithelium against Tobacco Smoke

Br Med J 1972; 2 doi: (Published 15 April 1972) Cite this as: Br Med J 1972;2:142
  1. Rosemary Jones,
  2. P. Bolduc,
  3. Lynne Reid


    Addition to tobacco of phenylmethyloxadiazole (PMO) protects rats against some of the adverse effects of exposure to cigarette smoke. Two groups of 15 rats were exposed to 25 cigarettes a day for 24 days; the group whose cigarette included PMO showed less immediate distress after exposure, a smaller tracheal goblet cell count, less thickening of the tracheal epithelium, and less cells in mitosis than those exposed to ordinary tobacco.