Papers And Originals

Distinction between Infection and Rejection in Lung Transplantation

Br Med J 1972; 2 doi: https://doi.org/10.1136/bmj.2.5805.71 (Published 08 April 1972) Cite this as: Br Med J 1972;2:71
  1. P. A. Cullum,
  2. M. Bewick,
  3. Keith Shilkin,
  4. D. E. H. Tee,
  5. P. Ayliffe,
  6. D. C. S. Hutchison,
  7. J. W. Laws,
  8. S. A. Mason,
  9. Lynne Reid,
  10. P. Hugh-Jones,
  11. A. M. Macarthur

    Abstract

    In distinguishing between infection and rejection after human lung transplantation clinical and radiological features were unhelpful, and even confusing. However, incipient rejection could be predicted and distinguished from infection by monitoring alterations in lymphocyte activity by the rosette inhibition test. Earlier prediction seems possible by detecting circulating lung-binding antibody. The ability to detect changes in the immunological status of a patient, even before clinical deterioration, has fundamental implications for the management of patients after transplantation.