Papers And Originals

Potassium-sparing Agents during Diuretic Therapy in Hypertension

Br Med J 1971; 2 doi: (Published 26 June 1971) Cite this as: Br Med J 1971;2:739
  1. T. J. McKenna,
  2. J. F. Donohoe,
  3. T. G. Brien,
  4. J. J. Healy,
  5. B. St. J. Canning,
  6. F. P. Muldowney


    Three pharmacological agents in use as “potassium-sparing” drugs have been tested by serial measurements of total exchangeable potassium (KE) during 4 to 12 weeks of oral diuretic therapy in hypertensive subjects. Triamterene seemed ineffective in the dosage used (50 mg twice daily). Spironolactone (25 mg twice daily) reduced K loss to a considerable extent, while Slow-K (32 mEq daily) completely reversed previous KE deficits. Plasma K levels were a poor indication of degree of KE restoration.