Papers And Originals

Recovery of Prostaglandins in Human Cutaneous Inflammation

Br Med J 1971; 2 doi: http://dx.doi.org/10.1136/bmj.2.5756.258 (Published 01 May 1971) Cite this as: Br Med J 1971;2:258
  1. Malcolm W. Greaves,
  2. Jørgen Søndergaard,
  3. Wendy McDonald-Gibson

    Abstract

    An in-vivo skin perfusion technique has been used to study the pharmacological activity in inflamed skin of patients with allergic contact eczema. Perfusates from 35 out of 45 patients contained a smooth-muscle-contracting agent with prostaglandin-like properties. Solvent partition followed by thinlayer chromatography revealed this activity to be due to a mixture of prostaglandins E and F. This direct evidence supports the view that prostaglandins mediate inflammation in man.

    Footnotes

    • * A brief report of this work was presented to the British Pharmacological Society, London, on 7 January 1971.