Miosis during L-Dopa TherapyBr Med J 1970; 2 doi: https://doi.org/10.1136/bmj.2.5710.639 (Published 13 June 1970) Cite this as: Br Med J 1970;2:639
- A. S. D. Spiers,
- D. B. Calne,
- P. M. Fayers
The pupillary diameter of 11 patients with Parkinson's disease was significantly decreased four hours after ingestion of L-dopa. It is suggested that this miosis may be caused by diminished noradrenaline output at sympathetic nerve endings, or alternatively by an action on the central nervous system.