Effect of RA233 on Platelet Function In VitroBr Med J 1970; 2 doi: https://doi.org/10.1136/bmj.2.5701.83 (Published 11 April 1970) Cite this as: Br Med J 1970;2:83
- A. A. Hassanein,
- A. G. G. Turpie,
- G. P. McNicol,
- A. S. Douglas
RA233, a new pyrimido-pyrimidine compound, is a powerful inhibitor of platelet function tested in vitro; it inhibits calcium and adenosine diphosphate (A.D.P.)-induced platelet aggregation, inhibits the retention of platelets by glass beads, decreases the release of platelet factor 3 by kaolin, and inhibits clot retraction. In some in-vitro systems RA233 is significantly more potent that its analogue RA433 in inhibiting platelet function.