Papers And Originals

Radioimmunoassay of Parathyroid Hormone in Primary Hyperparathyroidism: Studies after Removal of Parathyroid Adenoma

Br Med J 1969; 2 doi: http://dx.doi.org/10.1136/bmj.2.5660.789 (Published 28 June 1969) Cite this as: Br Med J 1969;2:789
  1. Richard M. Buckle

    Abstract

    Parathyroid hormone has been measured by radioimmunoassay in eight patients with hyperparathyroidism due to parathyroid adenoma. Secretion of hormone by the adenomatas was demonstrated direct by estimating the arteriovenous gradient of parathyroid hormone across the tumours. Serial estimations following surgical removal of the adenoma showed a rapid fall in the concentration of circulating parathyroid hormone. The calculated half-life of endogenously secreted parathyroid hormone in man varied from 11·4 to 28·8 min., with a mean of 19·8 min.