Papers And Originals

Calciphylaxis in Man

Br Med J 1969; 2 doi: http://dx.doi.org/10.1136/bmj.2.5658.670 (Published 14 June 1969) Cite this as: Br Med J 1969;2:670
  1. J. K. H. Rees,
  2. G. A. Coles

    Abstract

    A patient with renal failure developed widespread calcification in the thighs after the injection of iron-dextran (Imferon). This is considered as an example of calciphylaxis, a process in which calcium is laid down in parts of the body following the administration of a “challenger.” Iron-dextran is a known challenger, and should be used with caution in uraemic subjects, who may be sensitized by high serum parathyroid hormone levels. Contributing factors may have been a high calcium/phosphate product, steroids, and the patient's immobility.