Physiological Responses to Intermittent Methohexitone for Conservative DentistryBr Med J 1969; 2 doi: http://dx.doi.org/10.1136/bmj.2.5656.540 (Published 31 May 1969) Cite this as: Br Med J 1969;2:540
- C. C. Wise,
- John S. Robinson,
- M. J. Heath,
- P. J. Tomlin
Intermittent methohexitone for conservative dentistry has been shown to cause clinically undetectable respiratory obstruction, depression of the laryngeal reflex, and arterial hypoxaemia. Because of the pronounced decrease in total peripheral resistance, the blood pressure was maintained only by large increases in cardiac output. Furthermore, the output of the heart could not increase when challenged by hypoxia.