Papers And Originals

Action of a Pyrimido-pyrimidine Compound on Platelet Behaviour in Vitro

Br Med J 1969; 2 doi: https://doi.org/10.1136/bmj.2.5655.483 (Published 24 May 1969) Cite this as: Br Med J 1969;2:483
  1. C. D. Forbes,
  2. G. P. McNicol,
  3. A. S. Douglas

    Abstract

    A pyrimido-pyrimidine compound (RA433) was found in vitro to be a significantly more potent inhibitor of platelet behaviour than the previously available pyrimido-pyrimidine compound RA8—dipyridamole. In a turbidimetric system RA433 inhibits platelet aggregation induced by adenosine diphosphate, collagen, and noradrenaline; further, in a glass-bead-column technique it is a powerful inhiitor of platelet adhesiveness.