Preliminary Communications

Further Study into Obstructive Jaundice and Ischaemic Renal Damage

Br Med J 1969; 2 doi: https://doi.org/10.1136/bmj.2.5651.229 (Published 26 April 1969) Cite this as: Br Med J 1969;2:229
  1. M. Baum,
  2. G. A. Stirling,
  3. J. L. Dawson

    Abstract

    Renal ischaemia for one hour in two groups of Gunn rats, one with and the other without bile-duct ligation, produced comparable reversible renal tubular lesions in both groups. Since Gunn rats have an unconjugated hyperbilirubinaemia, which is unaffected by bile-duct ligation, it seems likely that the high levels of bilirubin glucuronide are responsible for sensitizing the renal tubules to ischaemia, possibly by depressing cell respiration.

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