Further Study into Obstructive Jaundice and Ischaemic Renal DamageBr Med J 1969; 2 doi: https://doi.org/10.1136/bmj.2.5651.229 (Published 26 April 1969) Cite this as: Br Med J 1969;2:229
- M. Baum,
- G. A. Stirling,
- J. L. Dawson
Renal ischaemia for one hour in two groups of Gunn rats, one with and the other without bile-duct ligation, produced comparable reversible renal tubular lesions in both groups. Since Gunn rats have an unconjugated hyperbilirubinaemia, which is unaffected by bile-duct ligation, it seems likely that the high levels of bilirubin glucuronide are responsible for sensitizing the renal tubules to ischaemia, possibly by depressing cell respiration.