Research Article

Immunoreactive beta-melanocyte-stimulating hormone in cerebrospinal fluid and plasma in hypopituitarism: evidence for an extrapituitary origin.

Br Med J 1977; 1 doi: http://dx.doi.org/10.1136/bmj.1.6072.1318 (Published 21 May 1977) Cite this as: Br Med J 1977;1:1318

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  1. S Shuster,
  2. A Smith,
  3. N Plummer,
  4. A Thody,
  5. F Clark

    Abstract

    Immunoreactive beta-melanocyte-stimulating hormone (beta-MSH) was measured in the plasma of 19 patients with hypopituitarism and in the cerebrospinal fluid (CSF) of five of these patients. In neither plasma nor CSF were the beta-MSH concentrations significantly different from those in normal controls. These observations raise the possibility that beta-MSH may be produced by and secreted from neural tissue; this is supported by the findings of beta-MSH in high concentrations in many parts of the brain.