Research Article

Prophylactic use of cephazolin against wound sepsis after cholecystectomy.

Br Med J 1977; 1 doi: (Published 14 May 1977) Cite this as: Br Med J 1977;1:1254
  1. C J Strachan,
  2. J Black,
  3. S J Powis,
  4. T A Waterworth,
  5. R Wise,
  6. A R Wilkinson,
  7. D W Burdon,
  8. M Severn,
  9. B Mitra,
  10. H Norcott


    A trial of antibiotic prophylaxis with cephazolin against postoperative wound sepsis was carried out on 201 patients undergoing routine cholecystectomy. Wound sepsis occurred in 11 out of 65 controls (16.9%), who were not given the drug; two out of 63 patients (3.2%) given a single dose preoperatively; and four out of 73 patients (5.5%) given the single preoperative dose plus a five-day course postoperatively. The difference between the controls and patients given the single preoperative dose was significant.