Research Article

Diagnosis of invasive candidosis by enzyme immunoassay of serum antigen.

Br Med J 1977; 1 doi: https://doi.org/10.1136/bmj.1.6070.1183 (Published 07 May 1977) Cite this as: Br Med J 1977;1:1183
  1. R C Warren,
  2. A Bartlett,
  3. D E Bidwell,
  4. M D Richardson,
  5. A Voller,
  6. L O White

    Abstract

    Enzyme immunoassay was used to measure Candida albicans-related antigen in sera of rabbits and mice infected with C albicans. A range of heterologous antigens tested gave no cross reactions. Of the three patients who were investigated and gave positive reactions, two were confirmed as having deep candida infections. Enzyme immunoassay is efficient, simple, and sensitive, and may prove valuable in the early diagnosis of invasive candida infections.