Research Article

Quinine-induced agranulocytosis: toxic effect of quinine bisulphate on bone marrow cultures in vitro.

Br Med J 1977; 1 doi: https://doi.org/10.1136/bmj.1.6061.605 (Published 05 March 1977) Cite this as: Br Med J 1977;1:605
  1. R Sutherland,
  2. P C Vincent,
  3. E Raik,
  4. K Burgess

    Abstract

    In a case of quinine-induced agranulocytosis marrow culture studies confirmed the inhibitory effect on the patient's cells of equivalent therapeutic plasma concentrations of quinine. Similar concentrations had no effect on normal marrow cells. Quinidine, the stereoisomer of quinine, had no effect on either cells from the patient or normal cells. The results encourage the use of in-vitro bone marrow cultures for identifying drugs responsible for agranulocytosis.