Immediate effects of tobramycin on human cochlea and correlation with serum tobramycin levels.Br Med J 1977; 1 doi: https://doi.org/10.1136/bmj.1.6056.259 (Published 29 January 1977) Cite this as: Br Med J 1977;1:259
- P Wilson,
- R T Ramsden
Electrocochleography was performed on three patients to monitor the intravenous administration of tobramycin. When peak serum tobramycin levels exceeded 8-10 mug/ml an immediate dramatic reduction in cochlear output was observed, which recovered fully as serum levels fell. The patients had no auditory or vestibular symptoms either during or after treatment.