A relation between HLA antigens and clinical features in patients with acquired valvular heart disease.Br Med J 1976; 1 doi: https://doi.org/10.1136/bmj.1.6024.1499 (Published 19 June 1976) Cite this as: Br Med J 1976;1:1499
- C Ward,
- K Gelsthorpe,
- R W Doughty
Analysis of the HLA antigen patterns in patients with acquired valvular heart disease showed that antigens A29 and AW30/31 occurred more often in those patients whose valvular disease was not preceeded by a history of rheumatic fever or chorea. Patients with no rheumatic history but with antigen A29 or AW30/31 had clinical features that distinguished them from others with valvular disease--namely, (a) isolated mitral valve disease and (b) the need for surgery, often at an early age, after a relatively short duration of symptoms.