Research Article

Untoward effects associated with practolol administration: oculomucocutaneous syndrome.

Br Med J 1975; 1 doi: http://dx.doi.org/10.1136/bmj.1.5958.595 (Published 15 March 1975) Cite this as: Br Med J 1975;1:595

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  1. P Wright

    Abstract

    Keratoconjunctivitis sicca, conjunctival scarring, fibrosis, metaplasia, and shrinkage developed in 27 patients as an adverse reaction to practolol. Rashes, nasal and mucosal ulceration, fibrous or plastic peritonitis, pleurisy, cochlear damage, and secretory otitis media also occurred in some cases. Three patients suffered profound visual loss though most retained good vision. Symptoms and signs improved on withdrawal of the drug, but reduction of tear secretion persisted in most patients.