Papers And Originals

Interaction between Doxycycline and Barbiturates

Br Med J 1974; 1 doi: https://doi.org/10.1136/bmj.1.5907.535 (Published 23 March 1974) Cite this as: Br Med J 1974;1:535
  1. P. J. Neuvonen,
  2. O. Penttilä

    Abstract

    In a cross-over study of five hospitalized patients the half life of doxycycline was significantly shortened after 10 days' treatment with phenobarbitone. In five patients on continuous barbiturate therapy the half life of doxycycline was even shorter. Barbiturates or other agents inducing drug metabolism should be used cautiously in combination with doxycycline, since this might result in therapeutically inadequate serum concentrations of the antibiotic.