Papers And Originals

Osteomalacia after Prolonged Glutethimide Administration

Br Med J 1973; 1 doi: https://doi.org/10.1136/bmj.1.5854.643 (Published 17 March 1973) Cite this as: Br Med J 1973;1:643

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  1. R. H. Greenwood,
  2. F. T. G. Prunty,
  3. J. Silver

    Abstract

    Vitamin D deficiency is a previously unreported complication of therapy with hypnotics, and we here report a case of osteomalacia associated with long-term glutethimide administration. There was evidence of pronounced hepatic enzyme induction, and the plasma half-time of 3H vitamin D3 was decreased by this drug. In addition, raised levels of serum gamma-glutamyl transpeptidase, 5-nucleotidase, and leucine aminopeptidase were observed and the patient excreted large amounts of xylulose. These changes were reversed by stopping the glutethimide.