Papers And Originals

Significance of Perfusate Lactic Acidosis in Cadaveric Renal Transplantation

Br Med J 1973; 1 doi: (Published 17 February 1973) Cite this as: Br Med J 1973;1:391
  1. R. W. G. Johnson,
  2. Marilyn Anderson,
  3. R. M. R. Taylor,
  4. John Swinney


    Thirty-two human cadaver kidneys were assessed by continuous perfusion before transplantation. Altogether, 26 were transplanted. Ten kidneys functioned immediately, of which nine had excellent renal function at three months. Sixteen had delayed onset of function, of these only five had excellent function at three months. There was no difference in warm ischaemic interval between the two groups or in ice storage time. The immediate function group, however, were perfused for twice as long as the delayed function group. The two groups could not be separated on donor history, but they could be precisely separated during perfusion by measuring lactic acidosis and lactic acid dehydrogenase (LDH). The biggest single difference between the groups was in terms of donor preparation.