Papers And Originals

Effect of Orally Administered Prostaglandin E2 and its 15-Methyl Analogues on Gastric Secretion

Br Med J 1973; 1 doi: https://doi.org/10.1136/bmj.1.5846.143 (Published 20 January 1973) Cite this as: Br Med J 1973;1:143
  1. S. M. M. Karim,
  2. D. C. Carter,
  3. D. Bhana,
  4. P. Adaikan Ganesan

    Abstract

    The effect of orally administered prostaglandin E2 and its synthetic 15-methyl analogues on gastric secretion in man was studied. The parent E2 compound did not inhibit basal secretion, whereas both the 15 (S) 15-methyl-E2 methyl ester and its isomer, 15 (R) 15-methyl-E2 methyl ester inhibited basal acid secretion. This action is likely to be a direct one on the parietal cell, and it could prove of value in the treatment of peptic ulcer.