Hyperlactataemia in Phenformin-treated DiabeticsBr Med J 1972; 1 doi: https://doi.org/10.1136/bmj.1.5794.205 (Published 22 January 1972) Cite this as: Br Med J 1972;1:205
- S. K. Varma,
- S. J. Heaney,
- W. G. Whyte,
- R. S. Walker
Raised fasting blood lactate levels were observed in diabetic patients on phenformin in therapeutic dosage. After an intravenous glucose load this effect was exaggerated and the lactate/pyruvate ratio increased. Withdrawal of the drug led to normal blood lactate levels and a fall in the lactate/pyruvate ratio.